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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Trifolirhizin, Sorafenib
Phytochemical Name Trifolirhizin (PubChem CID: 442827 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
Phytochemical
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Structure of
Anticancer Drug
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Sorafenib
Adverse Reactions Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug.
Recommendations Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium;
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.  ref_link
Combination Pair ID: 143
Pair Name Trifolirhizin, Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Down-regulation Expression AKT1 hsa207
Up-regulation Activity CASP3 hsa836
Up-regulation Activity CASP9 hsa842
Down-regulation Expression MAPK1 hsa5594
In Vitro Model MHCC97-H Adult hepatocellular carcinoma Homo sapiens (Human) CVCL_4972
In Vivo Model Each mouse was subcuta-neously inoculated in the right flank with 100μl PBS (PH 7.4) contain-ing 1.5×10⁶ HepG2 cells.
Result Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma
03. Reference
No. Title Href
1 Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma. Phytother Res. 2023 Feb;37(2):592-610. doi: 10.1002/ptr.7637. Click
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